"Requiem for a Dream" tells the interconnected stories of four characters: Harry Goldfarb (Jared Leto), a young heroin addict; Tyrone (Marlon Wayans), Harry's friend and partner in crime; Marion Silver (Jennifer Connelly), a young woman struggling with her own addiction and body image issues; and Sara Goldfarb (Ellen Burstyn), Harry's mother, who becomes obsessed with a diet pill that leads to her own downward spiral.