Kbi-058 May 2026

KBI-058, also known as Maralixibat, is a medication designed to treat certain liver diseases. It belongs to a class of drugs called apical sodium-dependent bile acid transporters (ASBT) inhibitors. The liver plays a crucial role in bile acid circulation, producing bile acids that help digest fats and absorb fat-soluble vitamins. Bile acids are then released into the intestines, where they aid in nutrient absorption, and a significant portion is reabsorbed back into the bloodstream, returning to the liver. This process is known as enterohepatic circulation.