The film begins with Dr. Bruce Banner (Eric Bana), a scientist working for a top-secret government project, General Thunderbolt Ross (Sam Elliott), and his colleague, Dr. Betty Ross (Giovanna Yager), attempting to cure a genetic disorder that causes Bruce to transform into the Hulk whenever he experiences extreme stress or anger. However, their experiments are shut down by the military, who seek to exploit the Hulk's incredible strength for their own gain.