The film is loosely based on the life of Giacomo Casanova, a famous Italian lover and adventurer. The story takes place in 18th-century Venice, where Casanova (played by Heath Ledger) is a charming and confident womanizer who has a reputation for seducing women. However, Casanova's life takes a turn when he meets Francesca (played by Sienna Guillory), a beautiful and independent woman who is not easily impressed by his charms.